2026-04-27T20:21:37Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/604252024-12-18T13:24:26Zcom_10324_1138com_10324_931com_10324_894col_10324_1226
UVaDOC author Varga Martínez, Olga de la author Martín Fernández, Marta author Heredia Rodríguez, María author Ceballos Laita, Luis author Cubero Gallego, Héctor author Priede Vimbela, Juan Manuel author Bardají Carrillo, Miguel author Sánchez de Prada, Laura author López Herrero, Rocío author Jorge Monjas, Pablo author Tamayo Gómez, Eduardo author Gómez Sánchez, Esther 2023-07-19T11:14:15Z 2023-07-19T11:14:15Z 2022 Journal of Clinical Medicine, 2022, Vol. 11, Nº. 24, 7274 2077-0383 https://uvadoc.uva.es/handle/10324/60425 10.3390/jcm11247274 7274 24 Journal of Clinical Medicine 11 2077-0383 Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction. eng Atribución 4.0 Internacional Heart - Surgery - Patients - Medical care Cardiac surgery Cardiology Cardiovascular, aparato - Cirugía Corazón - Cirugía Kidneys - Diseases Riñones - Enfermedades Nephrology Biochemical markers Nosocomial infections Infecciones de hospital Influence of renal dysfunction on the differential behaviour of procalcitonin for the diagnosis of postoperative infection in cardiac surgery info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/60425/1/Influence-of-Renal-Dysfunction-on-the-Differential-Behaviour-of-Procalcitonin.pdf File MD5 486051d623fc305783793db2c4966af7 1157246 application/pdf Influence-of-Renal-Dysfunction-on-the-Differential-Behaviour-of-Procalcitonin.pdf