2026-05-05T11:21:42Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/605312025-09-03T10:03:39Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

Effects of Withania somnifera (Ashwagandha) on hematological and biochemical markers, hormonal behavior, and oxidant response in healthy adults: A systematic review Gómez Afonso, Adrián Fernández Lázaro, Diego Adams, David P. Monserdà Vilaró, Aniol Fernández Lázaro, César Ignacio Producción Científica Purpose of Review Withania somnifera (L.) Dunal (Ws) is a common herb plant that has been used for centuries to treat a wide range of conditions, particularly certain chronic diseases due to its antidiabetic, cardioprotective, antistress, and chondroprotec- tive effects, among many others. No conclusive evidence, however, exists about the potential health effects of Ws in adults with- out chronic conditions. We aimed to evaluate the current evidence on the health benefits of Ws supplementation in healthy adults. Recent Findings Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed studies indexed in Web of Science, Scopus, and PubMed to assess the effects of Ws on hema- tological and biochemical markers, hormonal behavior, and oxidant response in healthy adults. Original articles published up to March 5, 2022, with a controlled trial design or pre-post intervention design, in which supplementation of Ws was compared to a control group or data prior to intervention were included. Among 2,421 records identified in the search, 10 studies met the inclusion criteria. Overall, most of the studies reported beneficial effects of the Ws supplementation, and no serious adverse events were reported. Participants supplemented with Ws displayed reduced levels of oxidative stress and inflammation, and counterbalanced hormone levels. No evidence of the beneficial effects of Ws supplementation on hematological markers was reported. Summary Ws supplementation appears to be safe, may regulate hormone levels, and has potent anti-inflammatory and anti- oxidant effects. However, further studies are needed to elucidate the relevance of its application. 2023-07-26T08:29:46Z 2023-07-26T08:29:46Z 2023 info:eu-repo/semantics/article Current Nutrition Reports, 2023. 2161-3311 https://uvadoc.uva.es/handle/10324/60531 10.1007/s13668-023-00481-0 Current Nutrition Reports 2161-3311 eng https://link.springer.com/article/10.1007/s13668-023-00481-0 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2023 The Author(s) Atribución 4.0 Internacional Springer SI