2026-04-27T21:46:46Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/606062025-02-19T07:28:15Zcom_10324_1179com_10324_931com_10324_894col_10324_1306
Luis Román, Daniel Antonio de
Primo Martín, David
Izaola Jauregui, Olatz
López Gómez, Juan José
2023-07-27T08:28:23Z
2023-07-27T08:28:23Z
2022
Nutrients, 2022, Vol. 14, Nº. 24, 5353
2072-6643
https://uvadoc.uva.es/handle/10324/60606
10.3390/nu14245353
5353
24
Nutrients
14
2072-6643
Producción Científica
Introduction: Dietary changes play a role in metabolic response of patients with metabolic-associated fatty liver disease, and there is little evidence on the use of partial meal replacement (pMR) diets in this pathology. Aim: We decided to evaluate the modifications in transaminases levels after a pMR hypocaloric diet in subjects with obesity and elevated fatty liver index (FLI). Material and methods: A sample of 606 patients with obesity and FLI ≥ 60 were enrolled and treated during 3 months with a pMR diet. Patients were divided as group I (Alanine amino transferase (ALT) normal) or group II (ALT ≥ 43 UI/L). Results: Body mass index, body weight, total fat mass, waist circumference, blood pressure, fasting glucose, total cholesterol, Low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, Homeostasis Model assessment (HOMA-IR), and FLI index improved significantly in the total group with pMR diet, without differences between group I and II. ALT, aspartate aminotransferase activity (AST), Gama glutamine transferase (GGT), and ratios of AST/ALT improved in both groups, too. This improvement was higher in group II (deltas group I vs. deltas group II); ALT (−4.2 ± 0.9 UI/L vs. −32.1 ± 5.7 UI/L: p = 0.01), AST (−4.8 ± 1.8 UI/L vs. −14.1 ± 1.9 UI/L: p = 0.02), GGT (−4.8 ± 1.4 UI/L vs. −37.1 ± 4.2 UI/L: p = 0.01), and AST/ALT ratio (−0.04 ± 0.002 units vs. −0.19 ± 0.04 units: p = 0.01). Conclusions: We reported that a pMR diet is an effective method to lose weight and to improve metabolic parameters in patients with obesity and high FLI. The decrease in liver parameters was greater in patients with ALT ≥ 43 UI/L.
application/pdf
eng
MDPI
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2022 The Authors
Atribución 4.0 Internacional
Fatty liver
Liver - Diseases
Hígado - Enfermedades
Obesity
Obesidad
Nutrition
Nutrition disorders
Enfermedades de la nutrición
Dietetics
Dietética
Regímenes alimentarios
Enzymes
Enzimas
3205.02 Endocrinología
3206 Ciencias de la Nutrición
Effects of a short-term meal replacement hypocaloric diet in subjects with obesity and high fatty liver index
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://www.mdpi.com/2072-6643/14/24/5353
SI