2026-04-27T19:54:45Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/60982026-01-13T13:20:57Zcom_10324_1134com_10324_931com_10324_894col_10324_1213

Expression and potential role of apolipoprotein D on the death–survival balance of human colorectal cancer cells under oxidative stress conditions Bajo Grañeras, Raquel Crespo Sanjuan, Jesús García Centeno, Rosa María Garrote Adrados, José Antonio Gutiérrez, Gabriel García Tejeiro, Manuel Aguirre Cervás, Beatriz Calvo Nieves, María Dolores Bustamante Bustamante, María Rosa Ganfornina Álvarez, María Dolores Sánchez Romero, Diego Colón - Cáncer - Tratamiento Purpose Inverse correlations of apolipoprotein D (ApoD) expression with tumor growth have been shown, therefore proposing ApoD as a good prognostic marker for diverse cancer types, including colorectal cancer (CRC). Besides, ApoD expression is boosted upon oxidative stress (OS) in many pathological situations. This study aims at understanding the role of ApoD in the progression of human CRC. Methods Samples of CRC and distant normal tissue (n051) were assayed for levels of lipid peroxidation, expression profile of OS-dependent genes, and protein expression. Three single-nucleotide polymorphisms in the ApoD gene were analyzed (n0139), with no significant associations found. Finally, we assayed the effect of ApoD in proliferation and apoptosis in the CRC HT-29 cell line. 2014-09-19T16:17:35Z 2014-09-19T16:17:35Z 2014-09-19T16:17:35Z 2013 info:eu-repo/semantics/article International Journal of Colorectal Disease, 2013, p. 1-18 0179-1958 http://uvadoc.uva.es/handle/10324/6098 10.1007/s00384-012-1616-2 1 18 International Journal of Colorectal Disease eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Springer-Verlag