2026-04-28T19:17:16Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/617992025-01-22T10:51:53Zcom_10324_1138com_10324_931com_10324_894col_10324_1226
Carrasco Serrano, Elena
Jorge Monjas, Pablo
Muñoz Moreno, María Fe
Gómez Sánchez, Esther
Priede Vimbela, Juan Manuel
Bardají Carrillo, Miguel
Cubero Gallego, Héctor
Tamayo Gómez, Eduardo
Ortega Loubon, Christian Joseph
2023-09-25T12:24:02Z
2023-09-25T12:24:02Z
2022
Journal of Clinical Medicine, 2022, Vol. 11, Nº. 11, 3046
2077-0383
https://uvadoc.uva.es/handle/10324/61799
10.3390/jcm11113046
3046
11
Journal of Clinical Medicine
11
2077-0383
One of the strongest risk factors for death in individuals undergoing cardiac surgery is Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI). Although the minimum kidney oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) has been reported, the optimal threshold value has not yet been established. A prospective study was conducted from June 2012 to January 2016 to asses how DO2i influences the pathogenesis of CSA-AKI, as well as its most favorable cut-off value. DO2 levels were recorded at the beginning, middle, and end of the CPB. The association between DO2i and CSA-AKI was investigated using multivariable logistic regression analysis. The optimal cut-off of DO2i as a predictor of CSA-AKI was determined using Classification and Regression Tree (CART) analysis. A total of 782 consecutive patients were enrolled. Of these, 231 (29.5%) patients developed AKI. Optimal DO2i thresholds of 303 mL/min/m2 during the CPB and 295 mL/min/m2 at the end of the intervention were identified, which increased the odds of CSA-AKI almost two-fold (Odds Ratio (OR), 1.90; 95% CI, 1.12–3.24) during the surgery and maintained that risk (OR 1.94; 95% CI, 1.15–3.29) until the end. Low DO2i during cardiopulmonary bypass is a risk factor for CSA-AKI that cannot be ruled out. Continuous renal oxygen supply monitoring for adult patients could be a promising method for predicting AKI during CPB.
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2022 The Authors
Atribución 4.0 Internacional
Nephrology
Kidneys - Diseases
Riñones - Enfermedades
Cardiac surgery
Cardiovascular, aparato - Cirugía
Heart - Surgery
Corazón - Cirugía
Cardiology
Cardiopulmonary bypass
Impact of oxygen delivery on the development of acute kidney injury in patients undergoing valve heart surgery
info:eu-repo/semantics/article