2026-05-05T21:08:09Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/619162023-10-09T19:02:43Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

00925njm 22002777a 4500 dc Noriega González, David César author Crespo Sanjuan, Jesús author Ardura Aragón, Francísco author Calabia del Campo, Juan author Alberola López, Carlos author Luis García, Rodrigo de author Caballero García, Alberto author Córdova Martínez, Alfredo author 2022 Adolescent idiopathic scoliosis (AIS) is characterized by the radiographic presence of a frontal plane curve, with a magnitude greater than 10° (Cobb technique). Diffusion MRI can be employed to assess the cerebral white matter. The aim of this study was to analyze, by means of MRI, the presence of any alteration in the connectivity of cerebral white matter in AIS patients. In this study, 22 patients with AIS participated. The imaging protocol consisted in T1 and diffusion-weighted acquisitions. Based on the information from one of the diffusion acquisitions, a whole brain tractography was performed with the MRtrix tool. Tractography is a method to deduce the trajectory of fiber bundles through the white matter based on the diffusion MRI data. By combining cortical segmentation with tractography, a connectivity matrix of size 84 × 84 was constructed using FA (fractional anisotropy), and the number of streamlines as connectomics metrics. The results obtained support the hypothesis that alterations in cerebral white matter connectivity in patients with adolescent idiopathic scoliosis (AIS) exist. We consider that the application of diffusion MRI, together with transcranial magnetic stimulation neurophysiologically, is useful to search the etiology of AIS. Children, 2022, Vol. 9, Nº. 7, 1023 2227-9067 https://uvadoc.uva.es/handle/10324/61916 10.3390/children9071023 1023 7 Children 9 2227-9067 Adolescent idiopathic scoliosis Scoliosis Escoliosis Adolescentes - Enfermedades Spine - Diseases - Treatment Columna vertebral - Anomalías - Tratamiento Magnetic resonance imaging Resonancia magnética Fractional anisotropy Connectomics Artificial intelligence Neurosciences Tractography Neurology Cerebral white matter connectivity in adolescent idiopathic scoliosis: A diffusion magnetic resonance imaging study