2026-04-27T21:53:50Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/622642025-02-19T12:06:23Zcom_10324_1134com_10324_931com_10324_894col_10324_1213

Córdova Martínez, Alfredo Caballero García, Alberto Bello Gutierrez, Hugo José Pons Biescas, Antoni Noriega González, David César Roche Collado, Enrique 2022 Producción Científica Aging is associated with a significant decline in neuromuscular function, leading to a reduction in muscle mass and strength. The aim of the present report was to evaluate the effect of supplementation with nitric oxide precursors (l-arginine and beetroot extract) in muscular function during a training period of 6 weeks in elderly men and women. The study (double-blind, placebo-controlled) involved 66 subjects randomly divided into three groups: placebo, arginine-supplemented and beetroot extract-supplemented. At the end of this period, no changes in anthropometric parameters were observed. Regarding other circulating parameters, urea levels were significantly (p < 0.05) lower in women of the beetroot-supplemented group (31.6 ± 5.9 mg/dL) compared to placebo (41.3 ± 8.5 mg/dL) after 6 weeks of training. In addition, the circulating creatine kinase activity, as an index of muscle functionality, was significantly (p < 0.05) higher in women of the arginine- (214.1 ± 162.2 mIU/L) compared to the beetroot-supplemented group (84.4 ± 36.8 mIU/L) at the end of intervention. No significant effects were noticed with l-arginine or beetroot extract supplementation regarding strength, endurance and SPPB index. Only beetroot extract supplementation improved physical fitness significantly (p < 0.05) in the sprint exercise in men after 6 weeks (2.33 ± 0.59 s) compared to the baseline (2.72 ± 0.41 s). In conclusion, beetroot seems to be more efficient during short-term training while supplementing, preserving muscle functionality in women (decreased levels of circulating creatine kinase) and with modest effects in men. application/pdf https://uvadoc.uva.es/handle/10324/62264 eng MDPI Aging Envejecimiento Creatine kinase Creatine Clinical nutrition Nutrición clínica Nutrition L-arginine Suplementos nutritivos Nitrate Nitratos Muscle strength Fuerza muscular Muscles - Aging Músculos - Envejecimiento Pharmacology 3206 Ciencias de la Nutrición 2402.15 Envejecimiento Somático 3209 Farmacología L-Arginine and beetroot extract supplementation in the prevention of sarcopenia info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana