2026-05-05T19:46:49Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/622642025-02-19T12:06:23Zcom_10324_1134com_10324_931com_10324_894col_10324_1213

00925njm 22002777a 4500 dc Córdova Martínez, Alfredo author Caballero García, Alberto author Bello Gutierrez, Hugo José author Pons Biescas, Antoni author Noriega González, David César author Roche Collado, Enrique author 2022 Aging is associated with a significant decline in neuromuscular function, leading to a reduction in muscle mass and strength. The aim of the present report was to evaluate the effect of supplementation with nitric oxide precursors (l-arginine and beetroot extract) in muscular function during a training period of 6 weeks in elderly men and women. The study (double-blind, placebo-controlled) involved 66 subjects randomly divided into three groups: placebo, arginine-supplemented and beetroot extract-supplemented. At the end of this period, no changes in anthropometric parameters were observed. Regarding other circulating parameters, urea levels were significantly (p < 0.05) lower in women of the beetroot-supplemented group (31.6 ± 5.9 mg/dL) compared to placebo (41.3 ± 8.5 mg/dL) after 6 weeks of training. In addition, the circulating creatine kinase activity, as an index of muscle functionality, was significantly (p < 0.05) higher in women of the arginine- (214.1 ± 162.2 mIU/L) compared to the beetroot-supplemented group (84.4 ± 36.8 mIU/L) at the end of intervention. No significant effects were noticed with l-arginine or beetroot extract supplementation regarding strength, endurance and SPPB index. Only beetroot extract supplementation improved physical fitness significantly (p < 0.05) in the sprint exercise in men after 6 weeks (2.33 ± 0.59 s) compared to the baseline (2.72 ± 0.41 s). In conclusion, beetroot seems to be more efficient during short-term training while supplementing, preserving muscle functionality in women (decreased levels of circulating creatine kinase) and with modest effects in men. Pharmaceuticals, 2022, Vol. 15, Nº. 3, 290 1424-8247 https://uvadoc.uva.es/handle/10324/62264 10.3390/ph15030290 290 3 Pharmaceuticals 15 1424-8247 Aging Envejecimiento Creatine kinase Creatine Clinical nutrition Nutrición clínica Nutrition L-arginine Suplementos nutritivos Nitrate Nitratos Muscle strength Fuerza muscular Muscles - Aging Músculos - Envejecimiento Pharmacology L-Arginine and beetroot extract supplementation in the prevention of sarcopenia