2026-04-27T14:37:33Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/622642025-02-19T12:06:23Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
L-Arginine and beetroot extract supplementation in the prevention of sarcopenia
Córdova Martínez, Alfredo
Caballero García, Alberto
Bello Gutierrez, Hugo José
Pons Biescas, Antoni
Noriega González, David César
Roche Collado, Enrique
Aging
Envejecimiento
Creatine kinase
Creatine
Clinical nutrition
Nutrición clínica
Nutrition
L-arginine
Suplementos nutritivos
Nitrate
Nitratos
Muscle strength
Fuerza muscular
Muscles - Aging
Músculos - Envejecimiento
Pharmacology
Producción Científica
Aging is associated with a significant decline in neuromuscular function, leading to a reduction in muscle mass and strength. The aim of the present report was to evaluate the effect of supplementation with nitric oxide precursors (l-arginine and beetroot extract) in muscular function during a training period of 6 weeks in elderly men and women. The study (double-blind, placebo-controlled) involved 66 subjects randomly divided into three groups: placebo, arginine-supplemented and beetroot extract-supplemented. At the end of this period, no changes in anthropometric parameters were observed. Regarding other circulating parameters, urea levels were significantly (p < 0.05) lower in women of the beetroot-supplemented group (31.6 ± 5.9 mg/dL) compared to placebo (41.3 ± 8.5 mg/dL) after 6 weeks of training. In addition, the circulating creatine kinase activity, as an index of muscle functionality, was significantly (p < 0.05) higher in women of the arginine- (214.1 ± 162.2 mIU/L) compared to the beetroot-supplemented group (84.4 ± 36.8 mIU/L) at the end of intervention. No significant effects were noticed with l-arginine or beetroot extract supplementation regarding strength, endurance and SPPB index. Only beetroot extract supplementation improved physical fitness significantly (p < 0.05) in the sprint exercise in men after 6 weeks (2.33 ± 0.59 s) compared to the baseline (2.72 ± 0.41 s). In conclusion, beetroot seems to be more efficient during short-term training while supplementing, preserving muscle functionality in women (decreased levels of circulating creatine kinase) and with modest effects in men.
2023-10-24T13:02:54Z
2023-10-24T13:02:54Z
2022
info:eu-repo/semantics/article
Pharmaceuticals, 2022, Vol. 15, Nº. 3, 290
1424-8247
https://uvadoc.uva.es/handle/10324/62264
10.3390/ph15030290
290
3
Pharmaceuticals
15
1424-8247
eng
https://www.mdpi.com/1424-8247/15/3/290
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2022 The Authors
Atribución 4.0 Internacional
MDPI
SI