2026-04-14T15:23:50Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/623842023-10-26T19:00:44Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

Usategui Martín, Ricardo Rigual Bonastre, Ricardo Jaime Ruiz Mambrilla, Marta María Fernández Gómez, José María Fidel Dueñas Laita, Antonio Pérez Castrillon, José Luis 2023-10-26T12:23:07Z 2023-10-26T12:23:07Z 2022 International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 6, 3233 1422-0067 https://uvadoc.uva.es/handle/10324/62384 10.3390/ijms23063233 3233 6 International Journal of Molecular Sciences 23 1422-0067 Producción Científica Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling. application/pdf eng MDPI info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2022 The Authors Atribución 4.0 Internacional Hypoxia Hipoxia Bone remodeling Bone health Huesos - Regeneración Bones - Metabolism - Disorders Huesos - Metabolismo, trastornos del Hypoxia Inducible Factor (HIF) Osteoclast Osteoblast Oxygen Oxígeno Cell Biology Medicine 2407 Biología Celular 32 Ciencias Médicas Molecular mechanisms involved in hypoxia-induced alterations in bone remodeling info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/1422-0067/23/6/3233 SI