2026-04-14T18:25:46Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/623842023-10-26T19:00:44Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

00925njm 22002777a 4500 dc Usategui Martín, Ricardo author Rigual Bonastre, Ricardo Jaime author Ruiz Mambrilla, Marta María author Fernández Gómez, José María Fidel author Dueñas Laita, Antonio author Pérez Castrillon, José Luis author 2022 Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling. International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 6, 3233 1422-0067 https://uvadoc.uva.es/handle/10324/62384 10.3390/ijms23063233 3233 6 International Journal of Molecular Sciences 23 1422-0067 Hypoxia Hipoxia Bone remodeling Bone health Huesos - Regeneración Bones - Metabolism - Disorders Huesos - Metabolismo, trastornos del Hypoxia Inducible Factor (HIF) Osteoclast Osteoblast Oxygen Oxígeno Cell Biology Medicine Molecular mechanisms involved in hypoxia-induced alterations in bone remodeling