2026-04-27T20:17:04Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/627042024-12-13T12:17:55Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
UVaDOC
author
Fernández Lázaro, Diego
author
Domínguez Ortega, Carlos
author
Sánchez Serrano, Nerea
author
Beddar Chaib, Fahd
author
Jerves Donoso, David
author
Jiménez Callejo, Elena
author
Rodríguez García, Saray
2023-11-07T13:42:36Z
2023-11-07T13:42:36Z
2022
Pharmaceutics, 2022, Vol. 14, Nº. 5, 1020
1999-4923
https://uvadoc.uva.es/handle/10324/62704
10.3390/pharmaceutics14051020
1020
5
Pharmaceutics
14
1999-4923
Coronavirus 2019 disease (COVID-19) represents one of the largest pandemics the world has faced, and it is producing a global health crisis. To date, the availability of drugs to treat COVID-19 infections remains limited to supportive care although therapeutic options are being explored. Some of them are old strategies for treating infectious diseases. convalescent plasma (CP) therapy has been used successfully in other viral outbreaks in the 20th century. In this study, we systematically evaluated the effect and safety of CP therapy on hospitalized COVID-19 patients. A structured search was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines using Medline (PubMed), SciELO, Cochrane Library Plus, Web of Science, and Scopus. The search included articles published up to January 2022 and was restricted to English- and Spanish-language publications. As such, investigators identified six randomized controlled trials that met the search criteria. The results determined that in hospitalized COVID-19 patients the administration of CP therapy with a volume between 200–500 mL and a single transfusion performed in 1–2 h, compared to the control group, decreased viral load, symptomatology, the period of infection, and mortality, without serious adverse effects. CP did influence clinical outcomes and may be a possible treatment option, although further studies will be necessary.
eng
Atribución 4.0 Internacional
SARS-CoV-2
COVID-19
Convalescent plasma
Plasma treatment
Plasma
Immunology
Viral load
Virology
Virus
Biomarkers
Mortality
Mortalidad
Public Health
Convalescent plasma therapy, therapeutic formulations of repurposed drugs in 20th century epidemics against COVID-19: A systematic review
info:eu-repo/semantics/article
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URL
https://uvadoc.uva.es/bitstream/10324/62704/1/Convalescent-Plasma-Therapy.pdf
File
MD5
da2b502f3b11feb2e07fa062cd25f06e
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application/pdf
Convalescent-Plasma-Therapy.pdf