2026-04-27T19:55:03Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/631842023-11-23T20:00:48Zcom_10324_40357com_10324_952com_10324_894col_10324_40358

Martínez Plaza, Elena Ruiz Fortes, Pedro Soto Negro, Roberto Hernández Rodríguez, Carlos J. Molina Martín, Ainhoa Arias Puente, Alfonso Piñero, David P. Eye - Diseases Ojo - Enfermedades y defectos Crystalline lens Cristalino - Enfermedades Cataract Cataratas (Oftalmología) Higher-order aberrations Ophthalmology Clinical biochemistry Bioquímica clínica Medical technology Producción Científica This study enrolled 61 volunteers (102 eyes) classified into subjects < 50 years (group 1) and subjects ≥ 50 years (group 2). Dysfunctional Lens Index (DLI); opacity grade; pupil diameter; and corneal, internal, and ocular higher order aberrations (HOAs) were measured with the i-Trace system (Tracey Technologies). Mean DLI was 8.89 ± 2.00 and 6.71 ± 2.97 in groups 1 and 2, respectively, being significantly higher in group 1 in all and right eyes (both p < 0.001). DLI correlated significantly with age (Rho = −0.41, p < 0.001) and pupil diameter (Rho = 0.20, p = 0.043) for all eyes, and numerous internal and ocular root-mean square HOAs for right, left, and all eyes (Rho ≤ −0.25, p ≤ 0.001). Mean opacity grade was 1.21 ± 0.63 and 1.48 ± 1.15 in groups 1 and 2, respectively, with no significant differences between groups (p ≥ 0.29). Opacity grade significantly correlated with pupil diameter for right and all eyes (Rho ≤ 0.33, p ≤ 0.013), and with some ocular root-mean square HOAs for right and all eyes (Rho ≥ 0.23, p ≤ 0.020). DLI correlates with age and might be used complementary to other diagnostic measurements for assessing the dysfunctional lens syndrome. Both DLI and opacity grade maintain a relationship with pupil diameter and internal and ocular HOAs, supporting that the algorithms used by the device may be based, in part, on these parameters. 2023-11-23 2023-11-23 2022 info:eu-repo/semantics/article Diagnostics, 2022, Vol. 12, Nº. 5, 1167 2075-4418 https://uvadoc.uva.es/handle/10324/63184 10.3390/diagnostics12051167 1167 5 Diagnostics 12 2075-4418 eng https://www.mdpi.com/2075-4418/12/5/1167 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2022 The Authors Atribución 4.0 Internacional MDPI