2026-05-05T20:25:34Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/638292025-01-22T09:07:14Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

Functional network properties in schizophrenia and bipolar disorder assessed with high-density electroencephalography Díez Revuelta, Álvaro Gómez Pilar, Javier Poza Crespo, Jesús Beño Ruiz De La Sierra, Rosa María Fernández Linsenbarth, Ines Recio Barbero, María Núñez Novo, Pablo Holgado Madera, Pedro Molina Rodríguez, Vicente Background: The study of the cortical functional network properties in schizophrenia (SZ) may benefit from the use of graph theory parameters applied to high-density electroencephalography (EEG). Connectivity Strength (CS) assesses global synchrony of the network, and Shannon Graph Complexity (SGC) summarizes the network distribution of link weights and allows distinguishing between primary and secondary pathways. Their joint use may help in understanding the underpinnings of the functional network hyperactivation and task-related hypomodulation previously described in psychoses. Methods: We used 64-sensor EEG recordings during a P300 oddball task in 128 SZ patients (96 chronic, CR, and 32 first episodes, FE), as well as 46 bipolar disorder (BD) patients, and 92 healthy controls (HC). Pre-stimulus and modulation (task-response minus pre-stimulus windows values) of CS and SGC were assessed in the theta band (4–8 Hz) and the broadband (4–70 Hz). Results: Compared to HC, SZ patients (CR and FE) showed significantly higher pre-stimulus CS values in the broadband, and both SZ and BD patients showed lower theta-band CS modulation. SGC modulation values, both theta-band and broadband, were also abnormally reduced in CR patients. Statistically significant relationships were found in the theta band between SGC modulation and both CS pre-stimulus and modulation values in patients. CS altered measures in patients were additionally related to their cognitive outcome and negative symptoms. A primary role of antipsychotics in these results was ruled out. Conclusions: Our results linking SGC and CS alterations in psychotic patients supported a hyperactive and hypomodulatory network mainly involving connections in secondary pathways. 2023-12-23T16:54:05Z 2023-12-23T16:54:05Z 2023-12-23T16:54:05Z 2024 info:eu-repo/semantics/article Progress in Neuropsychopharmacology & Biological Psychiatry 129 (2024) 110902 0278-5846 https://uvadoc.uva.es/handle/10324/63829 10.1016/j.pnpbp.2023.110902 110902 Progress in Neuro-Psychopharmacology and Biological Psychiatry 129 spa info:eu-repo/semantics/openAccess