2026-04-30T05:11:10Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/638722025-01-13T07:40:37Zcom_10324_1134com_10324_931com_10324_894col_10324_1213

López Cara, Luisa C. Camacho, M. Encarnación Carrión, M. Dora Tapias Molina, Victor Gallo, Miguel A. Escames, Germaine Acuña Castroviejo, Darío Espinosa, Antonio Entrena, Antonio 2009 Producción Científica We have previously described a series of 3-phenyl-4,5-dihydro-1H-pyrazole derivatives as moderately potent nNOS inhibitors. As a follow up of these studies, several new 5-phenyl-1H-pyrrole-2-carboxamide derivatives have been synthesized, and their biological evaluation as in vitro inhibitors of both neural and inducible Nitric Oxide Synthase (nNOS and iNOS) is described. Some of these compounds show good iNOS/nNOS selectivity and the more potent compounds 5-(2-aminophenyl)-1H-pyrrole-2-carboxilic acid methylamide (QFF205) and cyclopentylamide (QFF212) have been tested as regulators of the in vivo nNOS and iNOS activity. Both compounds prevented the increment of the inducible NOS activity in both cytosol (iNOS) and mitochondria (i-mtNOS) observed in the MPTP model of Parkinson's disease. application/pdf https://uvadoc.uva.es/handle/10324/63872 eng Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana