2026-05-05T20:21:10Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/638722025-01-13T07:40:37Zcom_10324_1134com_10324_931com_10324_894col_10324_1213

Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors López Cara, Luisa C. Camacho, M. Encarnación Carrión, M. Dora Tapias Molina, Victor Gallo, Miguel A. Escames, Germaine Acuña Castroviejo, Darío Espinosa, Antonio Entrena, Antonio We have previously described a series of 3-phenyl-4,5-dihydro-1H-pyrazole derivatives as moderately potent nNOS inhibitors. As a follow up of these studies, several new 5-phenyl-1H-pyrrole-2-carboxamide derivatives have been synthesized, and their biological evaluation as in vitro inhibitors of both neural and inducible Nitric Oxide Synthase (nNOS and iNOS) is described. Some of these compounds show good iNOS/nNOS selectivity and the more potent compounds 5-(2-aminophenyl)-1H-pyrrole-2-carboxilic acid methylamide (QFF205) and cyclopentylamide (QFF212) have been tested as regulators of the in vivo nNOS and iNOS activity. Both compounds prevented the increment of the inducible NOS activity in both cytosol (iNOS) and mitochondria (i-mtNOS) observed in the MPTP model of Parkinson's disease. 2024-01-01T20:58:53Z 2024-01-01T20:58:53Z 2024-01-01T20:58:53Z 2009 info:eu-repo/semantics/article European Journal of Medicinal Chemistry, Junio 2009, vol. 44, n. 6, p. 2655-2566 0223-5234 https://uvadoc.uva.es/handle/10324/63872 10.1016/j.ejmech.2008.11.013 2655 6 2666 European Journal of Medicinal Chemistry 44 eng info:eu-repo/semantics/embargoedAccess