2026-05-05T18:25:55Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/638992025-01-13T07:37:50Zcom_10324_1134com_10324_931com_10324_894col_10324_1213

00925njm 22002777a 4500 dc Tapias Molina, Victor author Moschonas, Eleni H. author Bondi, Corina O. author Vozzella, Vincent J. author Cooper, Iya N. author Cheng, Jeffrey P. author Lajud, Naima author Kline, Anthony E. author 2022 Traumatic brain injury (TBI) causes persistent cognitive impairment and neurodegeneration. Environmental enrichment (EE) refers to a housing condition that promotes sensory and social stimulation and improves cognition and motor performance but the underlying mechanisms responsible for such beneficial effects are not well defined. In this study, anesthetized adult rats received either a moderate-to-severe controlled cortical impact (CCI) or sham surgery and then were housed in either EE or standard conditions. The results showed a significant increase in protein nitration and oxidation of lipids, impaired cognition and motor performance, and augmented N-methyl-d-aspartate receptor subtype-1 (NMDAR1) levels. However, EE initiated 24 h after CCI resulted in reduced oxidative insult and microglial activation and significant improvement in beam-balance/walk performance and both spatial learning and memory. We hypothesize that following TBI there is an upstream activation of NMDAR that promotes oxidative insult and an inflammatory response, thereby resulting in impaired behavioral functioning but EE may exert a neuroprotective effect via sustained downregulation of NMDAR1. Experimental Neurology, Noviembre 2022, vol. 357. p. 114204 0014-4886 https://uvadoc.uva.es/handle/10324/63899 10.1016/j.expneurol.2022.114204 114204 Experimental Neurology 357 Environmental enrichment improves traumatic brain injury-induced behavioral phenotype and associated neurodegenerative process