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Gascoigne, Nicholas R. J. Casas Requena, Javier Brzostek, Joanna Rybakin, Vasily 2024-01-08T14:25:41Z 2024-01-08T14:25:41Z 2011 Frontiers Immunol. 2, (2011). https://uvadoc.uva.es/handle/10324/64298 10.3389/fimmu.2011.00072 Frontiers in Immunology 2 1664-3224 Producción Científica Recent data with CD8+T cells show that the initial phase ofT cell receptor (TCR) binding to MHC–peptide (MHCp) is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the bound TCR before the co-receptor binds to MHCp? Subvenciones NIH GM065230 y AI074074 a Nicholas R. J. Gascoigne. Este es el manuscrito 21444 de The Scripps Research Institute. application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional Initiation of TCR Phosphorylation and Signal Transduction info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion SI