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00925njm 22002777a 4500 dc Martín González, Elena author Sevilla, Teresa author Revilla Orodea, Ana author Casaseca de la Higuera, Juan Pablo author Alberola López, Carlos author 2020 Groupwise image (GW) registration is customarily used for subsequent processing in medical imaging. However, it is computationally expensive due to repeated calculation of transformations and gradients. In this paper, we propose a deep learning (DL) architecture that achieves GW elastic registration of a 2D dynamic sequence on an affordable average GPU. Our solution, referred to as dGW, is a simplified version of the well-known U-net. In our GW solution, the image that the other images are registered to, referred to in the paper as template image, is iteratively obtained together with the registered images. Design and evaluation have been carried out using 2D cine cardiac MR slices from 2 databases respectively consisting of 89 and 41 subjects. The first database was used for training and validation with 66.6–33.3% split. The second one was used for validation (50%) and testing (50%). Additional network hyperparameters, which are—in essence—those that control the transformation smoothness degree, are obtained by means of a forward selection procedure. Our results show a 9-fold runtime reduction with respect to an optimization-based implementation; in addition, making use of the well-known structural similarity (SSIM) index we have obtained significative differences with dGW with respect to an alternative DL solution based on Voxelmorph. Martín-González, E., Sevilla, T., Revilla-Orodea, A., Casaseca-de-la-Higuera, P., & Alberola-López, C. (2020). Groupwise non-rigid registration with deep learning: an affordable solution applied to 2D cardiac cine MRI reconstruction. Entropy, 22(6), 687 https://uvadoc.uva.es/handle/10324/64370 10.3390/e22060687 Groupwise Non-Rigid Registration with Deep Learning: An Affordable Solution Applied to 2D Cardiac Cine MRI Reconstruction