2026-04-28T19:26:09Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/645262025-03-07T08:16:40Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Martín Fernández, Marta Aller de la Fuente, Rocío Heredia Rodríguez, María Gómez Sánchez, Esther Martínez de Paz, Pedro José Gonzalo Benito, Hugo Sánchez de Prada, Laura Gorgojo Galindo, Óscar Carnicero Frutos, Irene Tamayo Gómez, Eduardo Tamayo Velasco, Álvaro 2024-01-15T14:28:31Z 2024-01-15T14:28:31Z 2021 Redox Biol. 2021 Nov 6;48:102181 2213-2317 https://uvadoc.uva.es/handle/10324/64526 10.1016/j.redox.2021.102181 102181 Redox Biology 48 Background: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in response to infections. A defective redox balance has been related to viral pathogenesis developing a massive induction of cell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profile evaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order to characterize its role in diagnosis and severity of this disease. Methods: Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/death risk was evaluated by multivariable regression analysis. Probability of intubation/death to day-28 was analyzed by using Kaplan-Meier curves and tested with the log-rank test. Results: Antioxidant enzymes (Superoxide dismutase (SOD) and Catalase) and oxidative cell damage (Carbonyl and Lipid peroxidation (LPO)) levels were significantly higher in COVID-19 patients while total antioxidant capacity (ABTS and FRAP) levels were lower in these patients. The comparison of oxidative stress molecules’ levels across COVID-19 severity revealed that only LPO was statistically different between mild and intubated/ death COVID-19 patients. COX multivariate regression analysis identified LPO levels over the OOP (LPO>1948.17 μM) as an independent risk factor for 28-day intubation/death in COVID-19 patients [OR: 2.57; 95% CI: 1.10–5.99; p = 0.029]. Furthermore, Kaplan-Meier curve analysis revealed that COVID-19 patients showing LPO levels above 1948.17 μM were intubated or died 8.4 days earlier on average (mean survival time 15.4 vs 23.8 days) when assessing 28-day intubation/death risk (p < 0.001). Conclusion: These findings deepen our knowledge of oxidative stress status in SARS-CoV-2 infection, supporting its important role in COVID-19. In fact, higher lipid peroxidation levels are independently associated to a higher risk of intubation or death at 28 days in COVID-19 patients. spa info:eu-repo/semantics/openAccess Lipid peroxidation as a hallmark of severity in COVID-19 patients info:eu-repo/semantics/article