2026-04-27T21:50:18Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/645732025-02-19T07:37:21Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Aller de la Fuente, Rocío Izaola Jauregui, Olatz Primo Martín, David Luis Román, Daniel Antonio de 2019 Objective: Some adiponectin gene (ADIPOQ) single-nucleotide polymorphisms (SNPs) have been related to basal and adiponectin levels and metabolic parameters. The aim of this study was to evaluate the effect of the genetic variant rs1501299 ADIPOQ gene on biochemical changes after weight loss secondary to a highprotein and low-carbohydrate diet versus a standard severe hypocaloric diet over 9 mo as the primary endpoint. Methods: A white population of 270 obese patients was enrolled in a randomized clinical trial with two hypocaloric diets (high-protein and low carbohydrate diet [HP] versus standard diet [S]) over 9 mo of intervention. The statistical analysis was performed for the combined GT and TT as a group (T-allele carriers) and GG as second group (non T-allele carriers). Before and after 12 wk on each hypocaloric diet, an anthropometric evaluation, an assessment of nutritional intake, and a biochemical analysis were realized. Results: With both dietary interventions, body weight, body mass index (BMI), fat mass, waist circumference, systolic blood pressure, and leptin levels decreased. In non T-allele carriers after both diets, the decrease in total cholesterol levels 12.3 § 2.2 mg/dL (T-allele carriers 6.9 § 2.1 mg/dL; P = 0.01 diet HP) and 12.2 § 3.1 mg/dL (T-allele carriers 4.7 § 1.2 mg/dL; P = 0.02 after diet S), low-density lipoprotein cholesterol 13.2 § 2.7 mg/dL (T-allele carriers 6.1 § 2.1 mg/dL; P = 0.02 after diet HP) and 9.3 § 1.8 mg/dL (T-allele carriers 4.8 § 2.9 mg/dL; P = 0.01 after diet S), triacylglycerol levels 12.7 § 6.1 mg/dL (T-allele carriers 6 § 2.9 mg/dL; P = 0.01 after diet HP) and 16.3 § 7.2 mg/dL (T-allele carriers 5.3 § 1.4 mg/dL; P = 0.03 after diet S), insulin levels 5 § 1.1 mUI/L (in T-allele 1.7 § 0.9 mUI/L; P = 0.02 after diet HP) and 3.2 1.1 mUI/L (T-allele carriers 0.7 § 0.7 mUI/L; P = 0.02 after diet S), and homeostatic model assessment of insulin resistance levels 0.4 § 0.2 units (T-allele group 0.1 § 0.1; P = 0.04 after diet HP) and 0.7 § 0.1 units (T-allele carriers 0.1 § 0.5 mg/dL; P = 0.01 after diet S) was higher than T-allele carriers. Only no T-allele carriers showed an increase in adiponectin levels after both diets. Conclusion: After two different hypocaloric diets during 9 mo of intervention, the GG genotype of an ADIPOQ gene variant (rs1501299) is related to better improvement in adiponectin levels, insulin resistance, and lipid profile than T-allele carriers application/pdf https://uvadoc.uva.es/handle/10324/64573 spa The effect of single-nucleotide polymorphisms at the ADIPOQ gene locus rs1501299 on metabolic parameters after 9 mo of a high-protein/low-carbohydrate versus a standard hypocaloric diet info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana