2026-04-27T19:53:20Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/647182024-01-18T20:01:32Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

Olivé-Cirera, Gemma Fonseca, Elianet Cantarín-Extremera, Verónica Vázquez-López, María Jiménez-Legido, María González-Álvarez, Verónica Ribeiro-Constante, Juliana Camacho-Salas, Ana Martí, Itxaso Martínez-González, María Jesús Saiz, Albert Armangué, Thaís 2024-01-18T08:43:27Z 2024-01-18T08:43:27Z 2022 Neurology Neuroimmunollogy & Neuroinflammation 2021 Jan 10;9(1):e1101 https://uvadoc.uva.es/handle/10324/64718 10.1212/NXI.0000000000001101 1 Neurology Neuroimmunology & Neuroinflammation 9 2332-7812 Background and Objectives To investigate whether children receiving immunosuppressive therapies for neuroimmunologic disorders had (1) increased susceptibility to SARS-CoV2 infection or to develop more severe forms of COVID-19; (2) increased relapses or autoimmune complications if infected; and (3) changes in health care delivery during the pandemic. Methods Patients with and without immunosuppressive treatment were recruited to participate in a retrospective survey evaluating the period from March 14, 2020, to March 30, 2021. Demographics, clinical features, type of immunosuppressive treatment, suspected or confirmed COVID-19 in the patients or cohabitants, and changes in care delivery were recorded. Results One hundred fifty-three children were included: 84 (55%) female, median age 13 years (interquartile range [8–16] years), 79 (52%) on immunosuppressive treatment. COVID-19 was suspected or confirmed in 17 (11%) (all mild), with a frequency similar in patients with and without immunosuppressive treatment (11/79 [14%] vs 6/74 [8%], p = 0.3085). The frequency of neurologic relapses was similar in patients with (18%) and without (21%) COVID19. Factors associated with COVID-19 included having cohabitants with COVID-19 (p <0.001) and lower blood levels of vitamin D (p = 0.039). Return to face-to-face schooling or mask type did not influence the risk of infection, although 43(28%) children had contact with a classmate with COVID-19. Clinic visits changed from face to face to remote for 120 (79%) patients; 110 (92%) were satisfied with the change. Discussion In this cohort of children with neuroimmunologic disorders, the frequency of COVID-19 was low and not affected by immunosuppressive therapies. The main risk factors for developing COVID-19 were having cohabitants with COVID-19 and low vitamin D levels application/pdf spa info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 Internacional Impact of COVID-19 in Immunosuppressed Children With Neuroimmunologic Disorders info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion SI