2026-04-22T21:53:23Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/649652025-03-10T13:21:44Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Gálvez Fernandez, Marta Grau Pérez, María García Barrera, Tamara Ramírez Acosta, Sara Gómez Ariza, José L. Pérez Gómez, Beatriz Galán Labaca, Iñaki Navas Acién, Ana Redón Mas, Josep Briongos Figuero, Laisa Socorro Dueñas Laita, Antonio Pérez Castrillon, José Luis Téllez Plaza, Maria Martín Escudero, Juan Carlos 2024-01-24T12:42:14Z 2024-01-24T12:42:14Z 2021 Free Radical Biology and Medicine, Enero 2021, vol.162, p. 392-400. 0891-5849 https://uvadoc.uva.es/handle/10324/64965 10.1016/j.freeradbiomed.2020.10.318 392 400 Free Radical Biology and Medicine 162 Background and objectives: Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association betweenAs, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representativesample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old. Methods: In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); plasma Se was measured by atomic absorption spectrometry (AAS) with graphite furnace; and BMD at the calcaneus was measured using the Peripheral Instaneuous X-ray Imaging system (PIXI). As levels were corrected for arsenobetaine (Asb) to account for inorganic As exposure. Results: The median of total urine As, Asb-corrected urine As, urine Cd, and plasma Se was 61.3, 6.53 and 0.39 μg/g creatinine, and 84.9 μg/L, respectively. In cross-sectional analysis, urine As and Cd were not associated with reduced BMD (T-score < -1 SD). We observed a non-linear dose-response of Se and reduced BMD, showing an inverse association below ~105 μg/L, which became increasingly positive above ~105 μg/L. The evaluated subgroups did not show differential associations. In prospective analysis, while we also observed a U-shape doseresponse of Se with the incidence of osteoporosis-related bone fractures, the positive association above ~105 μg/L was markedly stronger, compared to the cross-sectional analysis. Conclusions: Our results support that Se, but not As and Cd, was associated to BMD-related disease. The association of Se and BMD-related disease was non-linear, including a strong positive association with osteoporosisrelated bone fractures risk at the higher Se exposure range. Considering the substantial burden of bone loss in elderly populations, additional large prospective studies are needed to confirm the relevance of our findings to bone loss prevention in the population depending on Se exposure levels. eng info:eu-repo/semantics/openAccess Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study info:eu-repo/semantics/article