2026-04-30T05:16:45Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/649842024-01-25T20:00:44Zcom_10324_1138com_10324_931com_10324_894com_10324_40357com_10324_952col_10324_1226col_10324_40358
UVaDOC author Jurišić Dukovski, Bisera author Juretić, Marina author Bračko, Danka author Randjelović, Danijela author Savić, Snežana author Crespo Moral, Mario author Diebold Luque, María Yolanda author Filipović Grčić, Jelena author Pepić, Ivan author Lovrić, Jasmina 2024-01-25T09:36:59Z 2024-01-25T09:36:59Z 2020 International Journal of Pharmaceutics, 2020, vol. 576, 118979 0378-5173 https://uvadoc.uva.es/handle/10324/64984 10.1016/j.ijpharm.2019.118979 118979 International Journal of Pharmaceutics 576 Inflammation plays a key role in dry eye disease (DED) affecting millions of people worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) can be used topically to act on the inflammatory component of DED, but their limited aqueous solubility raises formulation issues. The aim of this study was development and optimization of functional cationic nanoemulsions (NEs) for DED treatment, as a formulation approach to circumvent solubility problems, prolong drug residence at the ocular surface and stabilize the tear film. Ibuprofen was employed as the model NSAID, chitosan as the cationic agent, and lecithin as the anionic surfactant enabling chitosan incorporation. Moreover, lecithin is a mixture of phospholipids including phosphatidylcholine and phosphatidylethanolamine, two constituents of the natural tear film important for its stability. NEs were characterized in terms of droplet size, polydispersity index, zeta-potential, pH, viscosity, osmolarity, surface tension, entrapment efficiency, stability, sterilizability and in vitro release. NEs mucoadhesive properties were tested rheologically after mixing with mucin dispersion. Biocompatibility was assessed employing 3D HCE-T cell-based model and ex vivo model using porcine corneas. The results of our study pointed out the NE formulation with 0.05% (w/w) chitosan as the lead formulation with physicochemical properties adequate for ophthalmic application, mucoadhesive character and excellent biocompatibility. eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional Oftalmología Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/64984/1/Functional-ibuprofen-loaded.pdf File MD5 f73196bbbcff5ddb6b43424c33c834dc 4063106 application/pdf Functional-ibuprofen-loaded.pdf