2026-04-14T18:10:11Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/652812024-10-17T13:16:09Zcom_10324_1148com_10324_931com_10324_894col_10324_1270

Quilez del Moral, José F. Domingo, Victoriano Pérez, Álvaro Martínez Andrade, Kevin A. López-Pérez, José Luis Barrero, Alejandro F. Enríquez Giraudo, María Lourdes Jaraíz Maldonado, Martín 2019 Producción Científica We have developed and rationalized a biomimetic transformation mimicking halimane synthases based on a Lewis acid-catalyzed cascade of cyclizations and rearrangements of epoxypolyprenes. Two rings, three stereogenic centers, and a new double bond were generated in a single chemical operation. Based on this cascade transformation, we achieved a unified strategy toward the stereoselective total syntheses of halimene-type terpenoids and analogues as a proof-of-concept study. This method has been applied to the rapid synthesis of diterpene isotuberculosinol, a virulence factor of Mycobacterium tuberculosis as a representative example. application/pdf https://uvadoc.uva.es/handle/10324/65281 eng American Chemical Society Mimicking Halimane Synthases: Monitoring a Cascade of Cyclizations and Rearrangements from Epoxypolyprenes info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana