2026-04-14T17:29:46Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/655222025-03-26T19:10:02Zcom_10324_1186com_10324_931com_10324_894col_10324_1404

Pérez Márquez, Lidia A. Perretti, Marcelle D. García Rodríguez, Raúl Lahoz, Fernando Carrillo, Romen 2024-02-01T13:41:18Z 2024-02-01T13:41:18Z 2022 Angew. Chem. Int. Ed. 2022, 61, e202205403; Angew. Chem. 2022, 134, e202205403 1433-7851 https://uvadoc.uva.es/handle/10324/65522 10.1002/anie.202205403 28 Angewandte Chemie 61 3-Nitrotyrosine (NT) is generated by the action of peroxynitrite and other reactive nitrogen species (RNS), and as a consequence it is accumulated in inflammation-associated conditions. This is particularly relevant in kidney disease, where NT concentration in blood is considerably high. Therefore, NT is a crucial biomarker of renal damage, although it has been underestimated in clinical diagnosis due to the lack of an appropriate sensing method. Herein we report the first fluorescent supramolecular sensor for such a relevant compound: Fluorescence by rotational restriction of tetraphenylethenes (TPE) in a covalent cage is selectively quenched in human blood serum by 3-nitrotyrosine (NT) that binds to the cage with high affinity, allowing a limit of detection within the reported physiological concentrations of NT in chronic kidney disease. eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional Química inorgánica A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum info:eu-repo/semantics/article