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oai:uvadoc.uva.es:10324/656092025-09-10T12:16:41Zcom_10324_1145com_10324_931com_10324_894col_10324_1254

00925njm 22002777a 4500 dc Barceló, Antonia author Peña, Mónica de la author Ayllón, Olga author Vega Agapito, María Victoria author Piérola, Javier author Pérez, Gerardo author González Martínez, Constancio author Alonso, Alberto author Agustí, Alvar GN author 2009 Cardiovascular (CV) diseases are a leading cause of mortality and they are frequent in patients with the obstructive sleep apnea syndrome (OSAS). Objectives: In this study we investigated if OSAS influences CV function independently of other CV risk factors frequently present in these patients (e.g. obesity, high blood pressure). Methods: We compared plasma markers of endothelial dysfunction, asymmetric dimethylarginine (ADMA) and endothelin-1 (ET- 1), and atherosclerosis progression (soluble fraction of the CD40 ligand, sCD40L) in OSAS patients with (n = 23) and without (n = 18) concurrent CV risk factors, as well as in healthy subjects (n = 23). Results: Plasma ADMA (p ! 0.01) and sCD40L (p ! 0.05) were abnormally increased in patients with OSAS versus healthy controls, but they were not influenced by the presence or absence of CV risk factors in OSAS. ET-1 levels were not different between the three groups of subjects studied. Conclusions: OSAS is associated with endothelial injury and atherosclerosis progression independently of other CV risk factors. Respiration, octubre 2009, vol. 77, p.85-90 https://uvadoc.uva.es/handle/10324/65609 10.1159/000165630 85 90 77 Increased Plasma Levels of Asymmetric Dimethylarginine and Soluble CD40 Ligand in Patients with Sleep Apnea