2026-04-14T17:49:01Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/656092025-09-10T12:16:41Zcom_10324_1145com_10324_931com_10324_894col_10324_1254

Increased Plasma Levels of Asymmetric Dimethylarginine and Soluble CD40 Ligand in Patients with Sleep Apnea Barceló, Antonia Peña, Mónica de la Ayllón, Olga Vega Agapito, María Victoria Piérola, Javier Pérez, Gerardo González Martínez, Constancio Alonso, Alberto Agustí, Alvar GN Producción Científica Cardiovascular (CV) diseases are a leading cause of mortality and they are frequent in patients with the obstructive sleep apnea syndrome (OSAS). Objectives: In this study we investigated if OSAS influences CV function independently of other CV risk factors frequently present in these patients (e.g. obesity, high blood pressure). Methods: We compared plasma markers of endothelial dysfunction, asymmetric dimethylarginine (ADMA) and endothelin-1 (ET- 1), and atherosclerosis progression (soluble fraction of the CD40 ligand, sCD40L) in OSAS patients with (n = 23) and without (n = 18) concurrent CV risk factors, as well as in healthy subjects (n = 23). Results: Plasma ADMA (p ! 0.01) and sCD40L (p ! 0.05) were abnormally increased in patients with OSAS versus healthy controls, but they were not influenced by the presence or absence of CV risk factors in OSAS. ET-1 levels were not different between the three groups of subjects studied. Conclusions: OSAS is associated with endothelial injury and atherosclerosis progression independently of other CV risk factors. 2024-02-02T23:27:13Z 2024-02-02T23:27:13Z 2009 info:eu-repo/semantics/article Respiration, octubre 2009, vol. 77, p.85-90 https://uvadoc.uva.es/handle/10324/65609 10.1159/000165630 85 90 77 eng https://karger.com/res/article-abstract/77/1/85/289644/Increased-Plasma-Levels-of-Asymmetric?redirectedFrom=fulltext info:eu-repo/semantics/restrictedAccess Karger Karger SI