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00925njm 22002777a 4500 dc León Ona, Iker author Alonso Alonso, Elena Rita author Mata López, Santiago author Cabezas, Carlos author Alonso Hernández, José Luis author 2019 Neutral glutamine has been evaporated by laserablation of its solid sample to seed a rare gas carrier prior toa supersonic expansion and proved by Fourier transformmicrowave techniques. We report on three distinct neutralconformers that show a singular non-interacting and flexibleamide sidechain in contrast with the other proteinogenicaliphatic amino acids. It could explain the essential biologicalrole of glutamine as a nitrogen source, and its unique ability toform a variety of hydrogen bonds with peptide backbones.Common computational methods fail to predict the delicatebalance of intramolecular interactions controlling the geome-try of the most stable conformer. The spectroscopic data herereported can be used to benchmark novel computationalmethods in quantum chemistry. Angewandte Chemie International Edition, 2019, 58, 16002 1433-7851 https://uvadoc.uva.es/handle/10324/65992 10.1002/anie.201907222 16002 45 16007 Angewandte Chemie International Edition 58 1521-3773 Unveiling the Neutral Forms of Glutamine