2026-04-14T17:43:18Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/659922025-03-04T09:47:24Zcom_10324_1186com_10324_931com_10324_894col_10324_1404

Unveiling the Neutral Forms of Glutamine León Ona, Iker Alonso Alonso, Elena Rita Mata López, Santiago Cabezas, Carlos Alonso Hernández, José Luis Producción Científica Neutral glutamine has been evaporated by laserablation of its solid sample to seed a rare gas carrier prior toa supersonic expansion and proved by Fourier transformmicrowave techniques. We report on three distinct neutralconformers that show a singular non-interacting and flexibleamide sidechain in contrast with the other proteinogenicaliphatic amino acids. It could explain the essential biologicalrole of glutamine as a nitrogen source, and its unique ability toform a variety of hydrogen bonds with peptide backbones.Common computational methods fail to predict the delicatebalance of intramolecular interactions controlling the geome-try of the most stable conformer. The spectroscopic data herereported can be used to benchmark novel computationalmethods in quantum chemistry. 2024-02-08T11:22:16Z 2024-02-08T11:22:16Z 2019 info:eu-repo/semantics/article Angewandte Chemie International Edition, 2019, 58, 16002 1433-7851 https://uvadoc.uva.es/handle/10324/65992 10.1002/anie.201907222 16002 45 16007 Angewandte Chemie International Edition 58 1521-3773 spa https://onlinelibrary.wiley.com/doi/10.1002/anie.201907222 info:eu-repo/semantics/restrictedAccess Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim WILEY-V C H VERLAG GMBH SI