2026-05-05T20:55:20Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/677742024-11-05T08:42:26Zcom_10324_1159com_10324_931com_10324_894col_10324_1310

Comparison of the ocular surface disease Index and the symptom assessment in dry eye questionnaires for dry eye symptom assessment Martín Herranz, Raúl Ocular Surface Disease Index (OSDI) Symptom Assessment iN Dry Eye (SANDE) Agreement Score normalization Background: Patient-reported dry eye symptoms (DESs), assessed using the Ocular Surface Disease Index (OSDI) and the Symptom Assessment iN Dry Eye (SANDE) questionnaires, were compared in a large sample of patients. Methods: The correlation (Spearman coefficient) and agreement (Bland-Altman analysis) between the OSDI and SANDE questionnaire scores (with and without score normalization) were assessed in 1033 patients and classified according to the OSDI score as non-DES and DES in a cross-sectional analysis. Results: The normalized and non-normalized SANDE results were higher than the OSDI results in all samples (2.83 ± 12.40 (p = 0.063) and 2.85 ± 15.95 (p = 0.016), respectively) and in non-DES (p > 0.063) and DES (p < 0.001) with both OSDI cutoff values. Weak correlations were found (Spearman coefficient < 0.53; p < 0.001) in all cases except DES (0.12, p = 0.126). Weak agreement was found with a Bland-Altman analysis of the normalized and non-normalized scores of both questionnaires (mean difference from −7.67 ± 29.17 (DES patients) to −1.33 ± 8.99 (non-DES patients) without score normalization, and from −9.21 ± 26.37 (DES patients) to −0.85 ± 4.01 (non-DES) with data normalization), with a statistically significant linear relationship (R2 > 0.32, p < 0.001). The SANDE questionnaire did not yield the same patient classification as OSDI. The same operative curves (ROC) of the SANDE normalized and non-normalized scores were used to differentiate among patients with DES using OSDI < 12 (0.836 ± 0.015) or OSDI < 22 (0.880 ± 0.015) cutoff values. Conclusions: Normalized and non-normalized data collected from the SANDE questionnaire showed relevant differences from those of the OSDI, which suggests that the results of the SANDE visual analog scale-based questionnaire provide different patient classifications than the OSDI score. 2024-05-22T12:09:15Z 2024-05-22T12:09:15Z 2024-05-22T12:09:15Z 2023 info:eu-repo/semantics/article Life, 2023, Vol. 13, Nº. 9, 1941 2075-1729 https://uvadoc.uva.es/handle/10324/67774 10.3390/life13091941 1941 9 Life 13 2075-1729 eng https://www.mdpi.com/2075-1729/13/9/1941 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2023 The authors Atribución 4.0 Internacional MDPI