2026-04-27T20:14:54Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/680982025-02-13T07:33:04Zcom_10324_1158com_10324_931com_10324_894col_10324_1242
UVaDOC
author
Espinosa, Ana
author
Reguera Gómez, Javier
author
Curcio, Alberto
author
Muñoz Noval, Álvaro
author
Kuttner, Christian
author
Van de Walle, Aurore
author
Liz Marzán, Luis M.
author
Wilhelm, Claire
2024-06-12T15:56:14Z
2024-06-12T15:56:14Z
2020
Small, 2020, 16 (11), 1904960
1613-6810
https://uvadoc.uva.es/handle/10324/68098
10.1002/smll.201904960
11
Small
16
1613-6829
Progress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the tumor site after systemic administration. Herein, the use of Janus magneto-plasmonic nanoparticles, made of gold nanostars and iron oxide nanospheres, as efficient therapeutic nanoheaters whose on-site delivery can be improved by magnetic targeting, is proposed. Single and combined magneto- and photo-thermal heating properties of Janus nanoparticles render them as compelling heating elements, depending on the nanoparticle dose, magnetic lobe size, and milieu conditions. In cancer cells, a much more effective effect is observed for photothermia compared to magnetic hyperthermia, while combination of the two modalities into a magneto-photothermal treatment results in a synergistic cytotoxic effect in vitro. The high potential of the Janus nanoparticles for magnetic guiding confirms them to be excellent nanostructures for in vivo magnetically enhanced photothermal therapy, leading to efficient tumor growth inhibition.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Janus magnetic‐plasmonic nanoparticles for magnetically guided and thermally activated cancer therapy
info:eu-repo/semantics/article
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IApwb3IgaW5jdW1wbGltaWVudG8gZGUgY3VhbHF1aWVyYSBkZSBsYXMgb2JsaWdhY2lvbmVzIGRlcml2YWRhcyBkZWwgQWN1ZXJkbywgcG9yIHZvbHVudGFkIGV4cHJlc2EgZGVsIEF1dG9yCkVuICBwcnVlYmEgZGUgY29uZm9ybWlkYWQsIGxhcyBwYXJ0ZXMgYWNlcHRhbiBlbCBwcmVzZW50ZSBBY3VlcmRvCgoKCgo=
URL
https://uvadoc.uva.es/bitstream/10324/68098/1/Janus-In%20vivo-magnetically-guided-PTT-Small.pdf
File
MD5
f5a66d1ed4c9ae87f2bce87f52027ed0
2347762
application/pdf
Janus-In vivo-magnetically-guided-PTT-Small.pdf