2026-04-28T21:14:50Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/689512025-09-11T06:51:03Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

Silicone microbubbles after anti‐vascular endothelial growth factor injections in patients with wet age‐related macular degeneration: incidence, quantification and secondary optical coherence tomography artfacts Sanabria Ruiz Colmenares, María Rosa Alonso Tarancón, Ana María Calles Monar, Paola Stefanía Ibañez, Patricia García de Arriba, Santiago Alvarez, Nuria Piñuel, Jesús A. Coco Martín, Rosa María Fernández Martínez, Itziar Producción Científica ABSTRACT. PURPOSE: To report the incidence and quantity of silicone oil microbubbles and the relationship with the number of intravitreal anti-vascular endothelial growth factor (VEGF) injections and evaluate if microbubbles induce artefacts on optical coherence tomography (OCT) images. METHODS: Observational, descriptive, cross-sectional study. Patients with wet age-related macular degeneration were included who had been treated for 1 year minimally with anti-VEGF injections repackaged in the hospital pharmacy. Detection and quantification of silicone microbubbles by mydriatic biomicroscopic examination were conducted 1 month after the last injection. The numbers of microbubbles were quantified on a scale of 0–3: 0, none; 1 scarce (1–10 microbubbles); 2 moderate (10–30); or 3 numerous (>30). Shadowing on OCT images was classified as 0–3: 0, none; 1 obscuring some retinal layers; 2 obscuring all retinal layers; or 3 obscuring the retinal thickness. RESULTS: The study included 142 eyes of 98 patients (mean age, 82.4 years + 7.3; range, 65–97) treated with 2377 injections. Microbubbles were detected in 127 (89.4%) eyes, 62 (43.6%) with numerous microbubbles and 36 (25.4%) and 29 (20.4%), respectively, with scarce and moderate numbers. A positive correlation was found between the numbers of injections and intravitreal silicone (rho, 0.7). Optical coherence tomography (OCT) artefacts were detected in 11 eyes; the artefacts obscured all retinal layers in three eyes. No significant relationship could be established between the appearance of floaters and the microbubbles. CONCLUSION: The presence and number of silicone microbubbles were correlated with the number of intravitreal injections. Microbubbles can produce OCT artefacts, which can hinder the treatment decision. 2024-07-22T10:03:20Z 2024-07-22T10:03:20Z 2021 info:eu-repo/semantics/article Acta Ophthalmol, Nov, 2021, vol. 99, n. 7, p. e1051-e1055. 1755-375X https://uvadoc.uva.es/handle/10324/68951 10.1111/aos.14743 e1051 7 e1055 Acta Ophthalmologica 99 1755-3768 spa https://pubmed.ncbi.nlm.nih.gov/33421336/ info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Wiley Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley Online Library SI