2026-04-27T21:50:07Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/697512025-02-20T09:49:21Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

00925njm 22002777a 4500 dc Escobedo Monge, Marlene Fabiola author Marcos Temprano, Marianela author Parodi Román, Joaquín author Escobedo Monge, María Antonieta author Alonso Vicente, Carmen author Torres Hinojal, María Carmen author Marugán de Miguelsanz, José Manuel author 2024 Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses. International Journal of Molecular Sciences, 2024, Vol. 25, Nº. 3, 1900 1422-0067 https://uvadoc.uva.es/handle/10324/69751 10.3390/ijms25031900 1900 3 International Journal of Molecular Sciences 25 1422-0067 Nutritional status Nutrición - Evaluación Calcium Calcio Phosphorus Fósforo Vitamina D Vitamina D Alkaline phosphatase Fosfatasa alcalina (Enzima) Physical activity Ejercicio físico Cystic fibrosis Fibrosis quística Lungs - Diseases Nutrition Medicine Calcium, phosphorus, and vitamin D levels in a series of cystic fibrosis patients: a cross-sectional study