2026-05-05T20:46:22Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/702612024-10-01T19:01:09Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

Feasibility and short-term outcomes in liver-first approach: a Spanish snapshot study (the RENACI project) Serradilla Martín, Mario Villodre, Celia Falgueras Verdaguer, Laia Zambudio Carroll, Natalia Castell Gómez, José T. Blas Laina, Juan L. Borrego Estella, Vicente Domingo del Pozo, Carlos García Plaza, Gabriel González Rodríguez, Francisco J. Montalvá Orón, Eva M. Moya Herraiz, Ángel Paterna López, Sandra Suárez Muñoz, Miguel A. Alkorta Zuloaga, Maialen Blanco Fernández, Gerardo Dabán Collado, Enrique Gómez Bravo, Miguel A. Miota de Llamas, José I. Rotellar, Fernando Sánchez Pérez, Belinda Sánchez Cabús, Santiago Pacheco Sánchez, David Rodríguez Sanjuan, Juan C. Varona Bosque, María A. Carrión Álvarez, Lucía Serna Esteban, Sofía de la Dopazo, Cristina Martín Pérez, Elena Martínez Cecilia, David Castro Santiago, María J. Dorcaratto, Dimitri Gutiérrez Díaz, Marta L. Asencio Pascual, José M. Burdío Pinilla, Fernando Carracedo Iglesias, Roberto Escartín Arias, Alfredo Ielpo, Benedetto Rodríguez Laiz, Gonzalo Valdivieso López, Andrés Vicente López, Emilio de Alonso Orduña, Vicente Ramia, José M. Colorectal cancer Colon - Cáncer Liver - Cancer Hígado - Cáncer Liver metastasis - Treatment Hígado - Metástasis Metástasis Hepatology Hepatologia Disease-free survival Survival Supervivencia Surgery Cancer - Research Cancer Oncology Public health - Spain Salud pública - España 3201.01 Oncología 3201 Ciencias Clínicas 3213 Cirugía 3212 Salud Publica Producción Científica Simple Summary: Current evidence does not provide enough information for selecting a tailored approach pathway in patients with colorectal cancer and synchronous liver metastases. There are no randomized clinical trials or prospective series comparing the classical approach with the liver-first approach. In addition, information on the proportion of patients who actually complete the therapeutic regimen is limited. The RENACI Project was a prospective National Registry performed on patients with colorectal cancer and synchronous liver metastases undergoing the liver-first approach. This study aimed to present the data of feasibility and short-term outcomes of the Spanish National Registry of Liver First Approach (the RENACI Project). (1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted. Asociación Española de Cirujanos - (grant Research Projects 2020) 2024-10-01T12:13:10Z 2024-10-01T12:13:10Z 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cancers, 2024, Vol. 16, Nº. 9, 1676 2072-6694 https://uvadoc.uva.es/handle/10324/70261 10.3390/cancers16091676 1676 9 Cancers 16 2072-6694 eng https://www.mdpi.com/2072-6694/16/9/1676 Atribución 4.0 Internacional info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2024 The authors application/pdf MDPI https://uvadoc.uva.es/bitstream/10324/70261/4/Feasibility-and-Short-Term-Outcomes-in-Liver-First-Approach.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by/4.0/ UVaDOC. Repositorio Documental de la Universidad de Valladolid https://uvadoc.uva.es/handle/10324/70261