2026-04-27T12:32:06Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/705402025-03-07T07:53:42Zcom_10324_1191com_10324_931com_10324_894col_10324_1379

Planchuelo Gómez, Álvaro García Azorín, David Guerrero Peral, Angel Luis Aja Fernández, Santiago Rodríguez Velasco, Margarita Luis García, Rodrigo de 2024-10-08T11:10:20Z 2024-10-08T11:10:20Z 2020 Cephalalgia, 2020, vol. 40, n. 4, p. 367-383 0333-1024 https://uvadoc.uva.es/handle/10324/70540 10.1177/0333102419885392 367 4 383 Cephalalgia 40 1468-2982 Objective: To identify possible structural connectivity alterations in patients with episodic and chronic migraine using magnetic resonance imaging data. Methods: Fifty-four episodic migraine, 56 chronic migraine patients and 50 controls underwent T1-weighted and diffusion-weighted magnetic resonance imaging acquisitions. Number of streamlines (trajectories of estimated fiber-tracts), mean fractional anisotropy, axial diffusivity and radial diffusivity were the connectome measures. Correlation analysis between connectome measures and duration and frequency of migraine was performed. Results: Higher and lower number of streamlines were found in connections involving regions like the superior frontal gyrus when comparing episodic and chronic migraineurs with controls (p<.05 false discovery rate). Between the left caudal anterior cingulate and right superior frontal gyri, more streamlines were found in chronic compared to episodic migraine. Higher and lower fractional anisotropy, axial diffusivity, and radial diffusivity were found between migraine groups and controls in connections involving regions like the hippocampus. Lower radial diffusivity and axial diffusivity were found in chronic compared to episodic migraine in connections involving regions like the putamen. In chronic migraine, duration of migraine was positively correlated with fractional anisotropy and axial diffusivity. Conclusions: Structural strengthening of connections involving subcortical regions associated with pain processing and weakening in connections involving cortical regions associated with hyperexcitability may coexist in migraine. Grants GRS 1727/A/18, GRS 943/A/14 Gerencia Regional de Salud CyL Grants RTI-2018-094569-B-I00, PRX18/00253 - Ministerio de Ciencia e Innovación, Spain application/pdf eng SAGE Publications info:eu-repo/semantics/restrictedAccess International Headache Society Migraine Chronic Migraine Diffusion-weighted imaging Tractography Magnetic resonance imaging (MRI) Connectomics Structural connectivity alterations in chronic and episodic migraine: A diffusion magnetic resonance imaging connectomics study info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion SI