2026-04-26T21:58:48Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/705462025-03-07T07:49:47Zcom_10324_1191com_10324_931com_10324_894col_10324_1379
UVaDOC author Planchuelo Gómez, Álvaro author Trigo López, Javier author Luis García, Rodrigo de author Guerrero Peral, Angel Luis author Porta Etessam, Jesús author García Azorín, David 2024-10-08T12:59:30Z 2024-10-08T12:59:30Z 2020 Frontiers in Neurology, 2020, vol. 11, p. 583870 https://uvadoc.uva.es/handle/10324/70546 10.3389/fneur.2020.583870 583870 Frontiers in Neurology 11 1664-2295 Objectives: Headache is a common symptom in systemic infections, and one of the symptoms of the novel coronavirus disease 2019 (COVID-19). The objective of this study was to characterize the phenotype of COVID-19 headache via machine learning. Methods: We performed a cross-sectional study nested in a retrospective cohort. Hospitalized patients with COVID-19 confirmed diagnosis who described headache were included in the study. Generalized Linear Models and Principal Component Analysis were employed to detect associations between intensity and self-reported disability caused by headache, quality and topography of headache, migraine features, COVID-19 symptoms, and results from laboratory tests. Results: One hundred and six patients were included in the study, with a mean age of 56.6 ± 11.2, including 68 (64.2%) females. Higher intensity and/or disability caused by headache were associated with female sex, fever, abnormal platelet count and leukocytosis, as well as migraine symptoms such as aggravation by physical activity, pulsating pain, and simultaneous photophobia and phonophobia. Pain in the frontal area (83.0% of the sample), pulsating quality, higher intensity of pain, and presence of nausea were related to lymphopenia. Pressing pain and lack of aggravation by routine physical activity were linked to low C-reactive protein and procalcitonin levels. Conclusion: Intensity and disability caused by headache attributed to COVID-19 are associated with the disease state and symptoms. Two distinct headache phenotypes were observed in relation with COVID-19 status. One phenotype seems to associate migraine symptoms with hematologic and inflammatory biomarkers of severe COVID-19; while another phenotype would link tension-type headache symptoms to milder COVID-19. eng Deep Phenotyping of Headache in Hospitalized COVID-19 Patients via Principal Component Analysis info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/70546/1/PlanchueloGomez2020_PhenotypingCOVID19.pdf File MD5 311b7e222abbf2bbc74b8eddee46531a 3810372 application/pdf PlanchueloGomez2020_PhenotypingCOVID19.pdf