2026-04-27T07:39:37Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/706072025-03-07T07:52:26Zcom_10324_1191com_10324_931com_10324_894col_10324_1379

00925njm 22002777a 4500 dc Trigo López, Javier author García Azorín, David author Planchuelo Gómez, Álvaro author García Iglesias, Cristina author Dueñas Gutiérrez, Carlos Jesús author Guerrero Peral, Angel Luis author 2020 Introduction: Headache is a common symptom of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this study, we aimed to characterize the phenotype of headache attributed to SARS-CoV-2 infection and to test the International Classification of Headache Disorders (ICHD-3) phenotypic criteria for migraine and tension-type headache. Methods: The study design was a cross-sectional study nested in a cohort. We screened all consecutive patients that were hospitalized and had a positive SARS-CoV-2 test. We included patients that described headache if the headache was not better explained by another ICHD-3 diagnosis. Patients were interviewed by two neurologists. Results: We screened 580 patients and included 130 (mean age 56 years, 64% female). Headache was the first symptom of the infection in 26% of patients and appeared within 24 hours in 62% of patients. The headache was bilateral in 85%, frontal in 83%, and with pressing quality in 75% of patients. Mean intensity was 7.1, being severe in 64%. Hypersensitivity to stimuli occurred in 57% of patients. ICHD-3 criteria for headache attributed to systemic viral infection were fulfilled by 94% of patients; phenotypic criteria for migraine were fulfilled by 25% of patients, and tension-type headache criteria by 54% of patients. Conclusion: Headache attributed to SARS-CoV-2 infection in hospitalized patients has severe intensity, frontal predominance and oppressive quality. It occurs early in the course of the disease. Most patients fulfilled ICHD-3 criteria for headache attributed to systemic viral infection; however, the phenotype might resemble migraine in a quarter of cases and tension-type headache in half of the patients. Cephalalgia 2020, vol. 40, n.13, p. 1432-1442 0333-1024 https://uvadoc.uva.es/handle/10324/70607 10.1177/0333102420965146 1432 13 1442 Cephalalgia 40 1468-2982 Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patients