2026-04-28T21:10:48Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/706072025-03-07T07:52:26Zcom_10324_1191com_10324_931com_10324_894col_10324_1379

Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patients Trigo López, Javier García Azorín, David Planchuelo Gómez, Álvaro García Iglesias, Cristina Dueñas Gutiérrez, Carlos Jesús Guerrero Peral, Angel Luis Introduction: Headache is a common symptom of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this study, we aimed to characterize the phenotype of headache attributed to SARS-CoV-2 infection and to test the International Classification of Headache Disorders (ICHD-3) phenotypic criteria for migraine and tension-type headache. Methods: The study design was a cross-sectional study nested in a cohort. We screened all consecutive patients that were hospitalized and had a positive SARS-CoV-2 test. We included patients that described headache if the headache was not better explained by another ICHD-3 diagnosis. Patients were interviewed by two neurologists. Results: We screened 580 patients and included 130 (mean age 56 years, 64% female). Headache was the first symptom of the infection in 26% of patients and appeared within 24 hours in 62% of patients. The headache was bilateral in 85%, frontal in 83%, and with pressing quality in 75% of patients. Mean intensity was 7.1, being severe in 64%. Hypersensitivity to stimuli occurred in 57% of patients. ICHD-3 criteria for headache attributed to systemic viral infection were fulfilled by 94% of patients; phenotypic criteria for migraine were fulfilled by 25% of patients, and tension-type headache criteria by 54% of patients. Conclusion: Headache attributed to SARS-CoV-2 infection in hospitalized patients has severe intensity, frontal predominance and oppressive quality. It occurs early in the course of the disease. Most patients fulfilled ICHD-3 criteria for headache attributed to systemic viral infection; however, the phenotype might resemble migraine in a quarter of cases and tension-type headache in half of the patients. 2024-10-08T16:22:12Z 2024-10-08T16:22:12Z 2020 info:eu-repo/semantics/article Cephalalgia 2020, vol. 40, n.13, p. 1432-1442 0333-1024 https://uvadoc.uva.es/handle/10324/70607 10.1177/0333102420965146 1432 13 1442 Cephalalgia 40 1468-2982 eng info:eu-repo/semantics/openAccess SAGE Publications SI