2026-04-14T17:12:14Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/720772024-12-02T10:12:02Zcom_10324_1166com_10324_931com_10324_894col_10324_1338

Alvarado Ramos, Katherine Bravo Núñez, Ángela Vairo, Donato Sabran, Charlotte Landrier, Jean‐François Reboul, Emmanuelle 2024 Producción Científica Scope: This study investigates whether vitamin E (VE) deficiency in subjects with obesity could, at least partly, be due to a defect in VE intestinal absorption. Methods and results: Mice follow either a high-fat (HF) or a control (CTL) diet for 12 weeks. The study evaluates their VE status, the expression of genes encoding proteins involved in lipid and fat-soluble vitamin intestinal absorption, and VE absorption using a 𝜸-tocopherol-rich emulsion. HF mice have a weight (+23.0%) and an adiposity index (AI, +157.0) superior to CTL mice (p < 0.05). 𝜶-Tocopherol concentrations are higher in both plasma (+45.0%) and liver (+116.9%) of HF mice compared to CTL mice (p < 0.05). 𝜶-Tocopherol concentration in the adipose tissue of HF mice is higher than that of CTL mice after correction by the AI (+72.4%, p < 0.05). No difference is found in the expression of genes coding for proteins involved in intestinal lipid metabolism in fasting mice. After force-feeding, 𝜸-tocopherol plasma concentration is higher in HF mice compared to CTL mice (+181.5% at 1.5 h after force-feeding, p < 0.05). Conclusion: HF mice display higher status and more efficient absorption of VE than CTL mice. VE absorption is thus likely not impaired in the early stages of obesity. application/pdf https://uvadoc.uva.es/handle/10324/72077 eng Wiley-VCH GmbH Overweight Leads to an Increase in Vitamin E Absorption and Status in Mice info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana