2026-04-27T21:30:17Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/720772024-12-02T10:12:02Zcom_10324_1166com_10324_931com_10324_894col_10324_1338

00925njm 22002777a 4500 dc Alvarado Ramos, Katherine author Bravo Núñez, Ángela author Vairo, Donato author Sabran, Charlotte author Landrier, Jean‐François author Reboul, Emmanuelle author 2024 Scope: This study investigates whether vitamin E (VE) deficiency in subjects with obesity could, at least partly, be due to a defect in VE intestinal absorption. Methods and results: Mice follow either a high-fat (HF) or a control (CTL) diet for 12 weeks. The study evaluates their VE status, the expression of genes encoding proteins involved in lipid and fat-soluble vitamin intestinal absorption, and VE absorption using a 𝜸-tocopherol-rich emulsion. HF mice have a weight (+23.0%) and an adiposity index (AI, +157.0) superior to CTL mice (p < 0.05). 𝜶-Tocopherol concentrations are higher in both plasma (+45.0%) and liver (+116.9%) of HF mice compared to CTL mice (p < 0.05). 𝜶-Tocopherol concentration in the adipose tissue of HF mice is higher than that of CTL mice after correction by the AI (+72.4%, p < 0.05). No difference is found in the expression of genes coding for proteins involved in intestinal lipid metabolism in fasting mice. After force-feeding, 𝜸-tocopherol plasma concentration is higher in HF mice compared to CTL mice (+181.5% at 1.5 h after force-feeding, p < 0.05). Conclusion: HF mice display higher status and more efficient absorption of VE than CTL mice. VE absorption is thus likely not impaired in the early stages of obesity. Alvarado‐Ramos, K., Bravo‐Núñez, Á., Vairo, D., Sabran, C., Landrier, J. F., & Reboul, E. (2024). Overweight Leads to an Increase in Vitamin E Absorption and Status in Mice. Molecular Nutrition & Food Research, 2400509. 1613-4125 https://uvadoc.uva.es/handle/10324/72077 10.1002/mnfr.202400509 Molecular Nutrition & Food Research 1613-4133 Overweight Leads to an Increase in Vitamin E Absorption and Status in Mice