2026-04-14T21:09:03Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/720772024-12-02T10:12:02Zcom_10324_1166com_10324_931com_10324_894col_10324_1338

Overweight Leads to an Increase in Vitamin E Absorption and Status in Mice Alvarado Ramos, Katherine Bravo Núñez, Ángela Vairo, Donato Sabran, Charlotte Landrier, Jean‐François Reboul, Emmanuelle Producción Científica Scope: This study investigates whether vitamin E (VE) deficiency in subjects with obesity could, at least partly, be due to a defect in VE intestinal absorption. Methods and results: Mice follow either a high-fat (HF) or a control (CTL) diet for 12 weeks. The study evaluates their VE status, the expression of genes encoding proteins involved in lipid and fat-soluble vitamin intestinal absorption, and VE absorption using a 𝜸-tocopherol-rich emulsion. HF mice have a weight (+23.0%) and an adiposity index (AI, +157.0) superior to CTL mice (p < 0.05). 𝜶-Tocopherol concentrations are higher in both plasma (+45.0%) and liver (+116.9%) of HF mice compared to CTL mice (p < 0.05). 𝜶-Tocopherol concentration in the adipose tissue of HF mice is higher than that of CTL mice after correction by the AI (+72.4%, p < 0.05). No difference is found in the expression of genes coding for proteins involved in intestinal lipid metabolism in fasting mice. After force-feeding, 𝜸-tocopherol plasma concentration is higher in HF mice compared to CTL mice (+181.5% at 1.5 h after force-feeding, p < 0.05). Conclusion: HF mice display higher status and more efficient absorption of VE than CTL mice. VE absorption is thus likely not impaired in the early stages of obesity. 2024-11-29T08:34:13Z 2024-11-29T08:34:13Z 2024 info:eu-repo/semantics/article Alvarado‐Ramos, K., Bravo‐Núñez, Á., Vairo, D., Sabran, C., Landrier, J. F., & Reboul, E. (2024). Overweight Leads to an Increase in Vitamin E Absorption and Status in Mice. Molecular Nutrition & Food Research, 2400509. 1613-4125 https://uvadoc.uva.es/handle/10324/72077 10.1002/mnfr.202400509 Molecular Nutrition & Food Research 1613-4133 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley-VCH GmbH SI