2026-05-05T21:26:48Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/725862025-02-13T07:36:36Zcom_10324_1158com_10324_931com_10324_894col_10324_1242
UVaDOC author López Méndez, Rosalía author Dubrova, Anastasiia author Reguera Gómez, Javier author Magro, Rául author Esteban Betegón, Fátima author Parente, Ana author García, Miguel Ángel author Camarero, Julio author Fonda, Emiliano author Wilhelm, Claire author Muñoz Noval, Álvaro author Espinosa, Ana 2024-12-16T09:16:21Z 2024-12-16T09:16:21Z 2024 Adv. Healthcare Mater. 2024, 2403799 2192-2640 https://uvadoc.uva.es/handle/10324/72586 10.1002/adhm.202403799 1 11 Advanced Healthcare Materials 2403799 2192-2659 In the pursuit of enhancing cancer treatment efficacy while minimizing side effects, near-infrared (NIR) photothermal therapy (PTT) has emerged as a promising approach. By using photothermally active nanomaterials, PTT enables localized hyperthermia, effectively eliminating cancer cells with minimal invasiveness and toxicity. Among these nanomaterials, gold nanostars (AuNS) stand out due to their tunable plasmon resonance and efficient light absorption. This study addresses the challenge of measuring nanoscale temperatures during AuNS-mediated PTT by employing X-ray absorption spectroscopy (XAS) within 3D tumor spheroids. It also aims to investigate the heat generated at the nanoscale and the resultant biological damage observed at a larger scale, utilizing confocal microscopy to establish connections between AuNS heat generation, tissue damage, and their impacts on cellular structure. These nanoscale and microscale thermal effects have been compared with macroscopic values obtained from infrared thermography, as part of a multiscale thermal analysis. The findings underscore the efficacy of AuNS in enhancing PTT and provide insights into the spatial distribution of thermal effects within tumor tissues. This research advances the understanding of localized hyperthermia in cancer therapy and underscores the potential of AuNS-based PTT for clinical applications. eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional Multiscale thermal analysis of gold nanostars in 3D tumor spheroids: integrating cellular‐level photothermal effects and nanothermometry via X‐ray spectroscopy info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/72586/1/Adv%20Healthcare%20Materials%20-%202024%20-%20L%c3%b3pez%e2%80%90M%c3%a9ndez%20-%20Multiscale%20Thermal%20Analysis%20of%20Gold%20Nanostars%20in%203D%20Tumor%20Spheroids%20%20%281%29.pdf File MD5 68fc7198c1ef4bd979531e9558a59de4 2822784 application/pdf Adv Healthcare Materials - 2024 - López‐Méndez - Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids (1).pdf