2026-05-05T20:00:21Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/727252025-01-31T10:35:22Zcom_10324_1159com_10324_931com_10324_894col_10324_1310

Abengózar Vela, Antonio Schaumburg, Chris S. Stern, Michael E. Calonge, Margarita Enriquez De Salamanca Aladro, Amalia González García, María Jesús Producción Científica Purpose: To determine the anti-inflammatory effect of quercetin (QCT), resveratrol (RES), and their combination in a dry eye disease (DED) model. Methods: DED was induced by exposing mice to a desiccating stress (DS); 0.01%QCT, 0.1%RES, 0.01%QCT+0.1%RES (QCT+RES) or vehicle were topically applied. Additionally, CD4+ T cells isolated from DS-exposed mice were transferred to athymic recipient mice. Corneal fluorescein staining, tear production and tear cytokine levels were evaluated in DS-exposed mice, and conjunctival CD4+ T cell infiltration was evaluated in recipient mice. Results: Corneal staining increased in DS-exposed mice, being reduced by QCT (p<0.001) and QCT+RES (p<0.05). DS induced an increase of IL-1α concentration that was reduced by QCT, RES and QCT+RES (p<0.05, 0.01 and 0.01, respectively). CD4+ T cells increased in recipients of DS-exposed mice (p<0.05), and was lower in recipients of QCT- and RES-treated mice (p<0.05). Conclusion: The anti-inflammatory effect of polyphenols suggests their topical application for DED. 2024-12-17 2024-12-17 2019 info:eu-repo/semantics/article Ocular Immunology and Inflammation, 2019;27:1023-1032 0927-3948 https://uvadoc.uva.es/handle/10324/72725 10.1080/09273948.2018.1497664 1023 6 1032 Ocular Immunology and Inflammation 27 1744-5078 eng https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1497664 info:eu-repo/semantics/restrictedAccess Taylor & Francis Taylor & Francis