2026-05-05T20:44:52Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/727262025-01-22T10:16:02Zcom_10324_1159com_10324_931com_10324_894col_10324_1310

Fernández Martínez, Itziar López Miguel, Alberto Martín Montañez, Vicente Enriquez De Salamanca Aladro, Amalia Calonge, Margarita González Méijome, José M. González García, María Jesús 2024-12-17T17:01:22Z 2024-12-17T17:01:22Z 2020 Ocular Surface, 2020;18:829-840 1542-0124 https://uvadoc.uva.es/handle/10324/72726 10.1016/j.jtos.2020.07.015 829 4 840 The Ocular Surface 18 Producción Científica Purpose: To characterize and predict the clinical and tear molecular response of contact lens (CL) wearers exposed to a controlled adverse desiccating environment (CADE). Methods: Objective and subjective variables and tear cytokine levels of monthly silicone hydrogel CL wearers were evaluated pre- and post-90 min of CADE exposure. Unsupervised hierarchical agglomerative clustering based on relative change from baseline values was used to identify response profiles (clusters). A multiple logistic regression model was used to identify cluster membership predictors. Results: Forty-seven CL wearers were divided into 3 clusters having similar age (mean: 27.7±7.7 years) and sex proportion. All of them showed a significant (p≤0.05) increase in limbal hyperemia and staining after CADE exposure. Additionally, Cluster-1 (n=22, 46.8%) membership was characterized by a significant (p≤0.05) higher worsening of corneal and limbal staining, increased CL wear symptoms, and reduced epidermal-growth-factor and increased interleukin (IL)-4 and IL-6 tear levels. Cluster-2 (n=22, 46.8%) showed no changes (p>0.05) in symptoms after CADE; however, their IL-12p70, monocytechemoattractant- protein-1 and regulated-on-activation, normal-T-cell-expressedand- secreted (RANTES) post-exposure tear levels significantly (p≤0.05) increased. Finally, Cluster-3 (n=3, 6.4%) mainly showed significant higher blink rate (78.1±21.7) during CADE. Corneal staining and tear IL-12p70 levels were identified as Cluster-1 membership predictors. Conclusions: Most of silicone hydrogel CL wearers exposed to CADE showed a worsening of the ocular surface and an upregulated tear inflammatory status. However, only half of them reported worsening of CL wear symptoms. These CL wearers were detected based on corneal integrity and tear inflammatory status. These findings can help reduce CL use discontinuation and drop out. Supported in part by the Spanish Ministry of Science, Innovation and Universities (Instituto de Salud Carlos III), through Research Projects RETICS (RD16/008/0001 grant) (OftaRed); and Biomedical Research Networking Center in Bioengineering; Biomaterials and Nanomedicine (CIBER-BBN) (CB06/01/003 grant). application/pdf eng Elsevier info:eu-repo/semantics/restrictedAccess Elsevier Contact lens discomfort, contact lens symptoms, controlled adverse desiccating environment, tear cytokines, cluster, predictors Inflammatory status predicts contact lens discomfort under adverse environmental conditions info:eu-repo/semantics/article info:eu-repo/semantics/draft https://www.sciencedirect.com/science/article/abs/pii/S1542012420301221?via%3Dihub SI