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oai:uvadoc.uva.es:10324/732582025-09-09T06:08:43Zcom_10324_1173com_10324_931com_10324_894col_10324_1371

Morales Palomo, Sergio Tomás Pejó, Elia González Fernández, María Cristina 2025-01-09T08:08:55Z 2025-01-09T08:08:55Z 2024 Environmental Technology & Innovation, noviembre 2024, vol. 36, 103767 2352-1864 https://uvadoc.uva.es/handle/10324/73258 10.1016/j.eti.2024.103767 103767 Environmental Technology & Innovation 36 Producción Científica Some oleaginous yeasts have the ability to produce microbial oils from alternative carbon sources, such as short-chain fatty acids (SCFAs). Nevertheless, there is still a lack of information about the possible effects that media nutrients have on yeast metabolisms when using SCFAs. For instance, inorganic phosphate (PO43-) has been reported to promote yeast growth in literature but its chelating effect over other elements such as calcium (Ca2+) is often not considered in fermentation processes while limitation of nitrogen is probably the most studied. Attending at the need to better understand the role of PO43-, this work assessed the lipid production capacity of Yarrowia lipolytica ACA DC 50109, both in synthetic and real SCFAs-rich media, at different SCFAs concentrations and PO43-:Ca2+ ratios. Reducing PO43-:Ca2+ ratio was identified to be an important factor to improve yeast growth, reaching the highest lipid content (52.7 ± 0.9 % w/w) and lipid yield (0.31 ± 0.01 w/w) in media without PO43-. These results demonstrated the importance of Ca2+ availability in the medium and nutrients interactions in yeast growth that are often underestimated. Ministerio de Ciencia e Innovación (PID2020-119403RBC21, PCI2021-121936, PRE2018-086477, RYC2019-027773-I) application/pdf eng Elsevier info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc/4.0/ © 2024 The Authors Atribución-NoComercial 4.0 Internacional Phosphate Calcium Chelation Lipids Yarrowia lipolytica Short-chain fatty acids Phosphate chelation over calcium impacts yeast growth and lipid production from short-chain fatty acids-rich media info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S2352186424002438 SI