2026-04-14T17:00:44Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/736932025-02-19T07:37:00Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Role of rs2282679 in 25-hydroxyvitamin D levels and insulin resistance after a sleeve gastrectomy Luis Román, Daniel Antonio de Izaola Jauregui, Olatz Primo Martín, David López Gómez, Juan José Pacheco Sánchez, David BACKGROUND & AIMS: Some studies have reported links between 25-hydroxyvitamin D levels and the presence of obesity and some genetic variants. The aim of our design was to evaluate the effects of rs2282679 genetic variant of CG gene on 25- hydroxyvitamin D levels, weight loss and metabolic parameters after a robotic sleeve gastrectomy in premenopausal females with obesity. METHODS: 76 participants were enrolled. 25-hydroxyvitamin D levels, biochemical evaluation and anthropometric parameters were registered before surgery and after 3, 6 and 12 months follow up. Genotype of rs2282679 CG gene was evaluated. RESULTS: The improvements in anthropometric parameters, blood pressure and lipid profile were similar in both genotypes (TT vs TG+ GG). Basal insulin levels and HOMA-IR were greater in G allele carriers than non-carriers (Delta: 6.7 ± 1.2 mUI/L; p = 0.01) and (Delta: 1.3 ± 0.1 units; p =0.02). 25-hydroxyvitamin D levels were lower in G allele carriers than non-carriers (Delta: 8.1 ± 1.1 ng/dl; p =0.03). The levels of insulin and HOMA-IR remained greater in G allele carriers than non-carriers throughout all the visits. The levels of 25-hydroxyvitamin D remained lower in G allele carriers than non-G allele. The average level of 25-hydroxyvitamin D at 12 months in non-G allele carriers were above 30 ng/dl (36.0 ± 3.1 ng/dl) and the level in G allele carriers were below (24.9 ± 4.9 ng/dl). CONCLUSIONS: rs 2282679 (GC) was related with low 25 hydroxyvitamin D levels and insulin resistance. In addition, the presence of G allele produced a decrease in the improvement of 25-hydroxyvitamin D levels and insulin resistance after weight loss during 12 months. 2025-01-11T12:18:44Z 2025-01-11T12:18:44Z 2024 info:eu-repo/semantics/article Nutrition and Diabetes, 2024, vol. 14, 12 https://uvadoc.uva.es/handle/10324/73693 10.1038/s41387-024-00272-8 1 Nutrition & Diabetes 14 2044-4052 spa https://www.nature.com/articles/s41387-024-00272-8 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional SI