2026-04-23T20:26:46Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/736952025-02-26T08:18:56Zcom_10324_1179com_10324_931com_10324_894col_10324_1306
Management of disease-related malnutrition: a real-world experience with a novel concentrated high-protein energy-dense oral nutritional supplement
López Gómez, Juan José
Ramos Bachiller, Beatriz
Luis Román, Daniel Antonio de
Objective: Despite the availability of a wide range of oral nutritional supplements (ONS) offerings,
individuals with malnutrition are still struggling to meet their nutritional targets. A new concentrated
and high-protein energy-dense ONS (≥2.1 kcal/mL;32 g protein/200 mL) with high-quality protein (60%
whey protein) has emerged as a pivotal formula to reach the patient’s energy-protein requirements,
enhance compliance, and maximize stimulation of muscle protein synthesis, key factors driving better
nutritional, functional, and clinical outcomes. The purpose of this article is to provide our clinical
experience using this new nutritionally concentrated ONS as a therapeutic strategy for patients with
DRM.
Methods: Three clinical cases have been examined using new assessment procedures and a new form
of nutritional therapy, and their impact on the nutritional and functional outcomes in patients with
moderate-to-severe DRM.
Results: A tailored individualized nutritional interventions improved anthropometric, biochemical, and
functional outcomes (Case 1,2, and 3) assessed using hand grip strength, bioimpedance and muscle
ultrasound, and as well as good gastrointestinal tolerance (Case 1) and compliance to the ONS in
patients with DRM (Case 1,2,3).
Conclusion: The use of this novel high-protein energy-dense formula with high-quality protein source
(≥2.1 kcal/mL; 32 g protein/200 mL; 60% whey protein) overcome common practical challenges in the
medical nutrition therapy of patients with DRM, either because these patients require a highly concentrated
formulation to meet nutritional requirements due to loss of appetite, lack of interest in food,
and high caloric-protein needs due to disease, and a large quantity and quality of protein to optimize
muscle recovery due to sarcopenia, common in patients with moderate-severe malnutrition.
2025-01-11
2025-01-11
2024
info:eu-repo/semantics/article
Postgraduate Medicine, 2024, vol. 136, n. 1, p. 52-59.
0032-5481
https://uvadoc.uva.es/handle/10324/73695
10.1080/00325481.2024.2307869
52
1
59
Postgraduate Medicine
136
1941-9260
eng
https://www.tandfonline.com/doi/full/10.1080/00325481.2024.2307869
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/
Atribución-NoComercial-SinDerivados 4.0 Internacional