2026-04-27T21:54:49Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/738822025-03-26T16:41:30Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
UVaDOC
author
Ruiz Martín, Virginia
author
Marcos, Tamara
author
de Pereda, José María
author
Sánchez Crespo, Mariano
author
Fuente García, Miguel Ángel de la
author
Bayón Prieto, Yolanda
author
Alonso, Andrés
2025-01-15T14:35:32Z
2025-01-15T14:35:32Z
2024
Biological Research volume 57, Article number: 69 (2024)
https://uvadoc.uva.es/handle/10324/73882
10.1186/s40659-024-00536-8
1
69
14
LYP regulates SLP76 and other adaptor proteins in T cells
volume 57
Background
The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the development of these diseases. The scarce information about LYP substrates is in part responsible for the poor understanding of LYP function.
Results
In this study, we identify in T lymphocytes several adaptor proteins as potential substrates targeted by LYP, including FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2. We also show that LYP co-localizes with SLP76 in microclusters, upon TCR engagement.
Conclusions
These data indicate that LYP may modulate T cell activation by dephosphorylating several adaptor proteins, such as FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2 upon TCR engagement.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Biomedicina
LYP regulates SLP76 and other adaptor proteins in T cells
info:eu-repo/semantics/article
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s40659-024-00536-8(Biological Research 2024).pdf