2026-04-30T05:15:42Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/748212025-02-04T20:01:34Zcom_10324_22821com_10324_954com_10324_894col_10324_22822

Martínez García, María del Henar Santos García, María Mercedes Pedraza, Lucía Testera Gorgojo, Ana María 2024 Producción Científica Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structural point of view and with few exceptions, MNPs of pharmaceutical importance derive from the so-called secondary metabolism of marine organisms. When production strategies relied on marine macroorganism, harvesting or culturing coupled with extraction procedures re-main sometimes the only alternative to produce these compounds at industrial scale. Their supply can be often implemented with laboratory scale cultures for bacterial, fungal or microalgal sources. However, a diverse approach, combining traditional methods with a modern synthetic biology and biosynthesis strategies, must be considered for invertebrate MNPs, as they are usually naturally accumulated in only very small quantities. This review offers a comprehensive examination of various production strategies for MNPs, addressing the challenges related to supply, synthesis, and scalability. It also underscores recent biotechnological advancements that are likely to transform the current industrial-scale manufacturing methods for pharmaceuticals derived from marine sources. application/pdf https://uvadoc.uva.es/handle/10324/74821 eng MDPI 2306 Química Orgánica Advanced technologies for marine drugs large scale supply info:eu-repo/semantics/article TEXT UVaDOC. Repositorio Documental de la Universidad de Valladolid Hispana